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Implications of astrocytes in neurovascular coupling
You ZHOU MD, Chang-Kai SUN MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 43-45 doi: 10.1007/s11684-010-0019-4
王威琪,汪源源,余建国,吴晓峰,刘斌,张羽,陈斯中,仪艳华,邵谦明
《中国工程科学》 2001年 第3卷 第2期 页码 52-64
人体信号是随机性和背景噪声都很强的复杂信号。文章首先研究了利用超声Doppler技术定量检测血流速度的方法,然后将一些现代信息处理中的新理论、新方法引入医学超声的信息处理,为医学超声信息的特征提取提供了新的手段。这些理论包括:分形、数学形态学、数量化、小波变换、极点轨迹和血管传输线模型等。文章最后阐述了利用上述新方法作为技术核心而研制的三套应用系统;肺动脉血液动力学参数的无损估测系统、彩色编码的声谱系统和超声血流定量检测系统。
Non-invasive continuous blood pressure monitoring: a review of current applications
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 91-101 doi: 10.1007/s11684-013-0239-5
Blood pressure monitoring has come a long way from the initial observations made by Reverend Hales in the 18th century. There are none that deny the importance of monitoring perioperative blood pressure; however, the limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuous blood pressure measurements leaves room for improvement. Invasive monitoring is able to detect beat-to-beat blood pressure measurement, but the risks inherent to the procedure make it unsuitable for routine use except when this risk is outweighed by the benefits. This review focuses on the discoveries which have led up to the current blood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous blood pressure monitoring capabilities, including their methods of measurement and limitations.
关键词: non-invasive blood pressure monitoring continuous blood pressure monitoring invasive blood pressure monitoring Riva-Rocci technique oscillometric Pe?áz technique arterial tonometry pulse transit time
TANG Zhongzhi, LI Junyao, YANG Jianhong
《医学前沿(英文)》 2008年 第2卷 第2期 页码 178-181 doi: 10.1007/s11684-008-0033-y
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 86-93 doi: 10.1007/s11684-011-0118-x
Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo. In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO). We found that AAV vectors did not elicit a detectable inflammatory response, cell loss or neuronal damage after brain transduction. The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice. Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals (P<0.05) 7 days after tMCAO. Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.
关键词: adeno-associated virus angiogenesis gene transfer ischemia middle cerebral artery occlusion netrin-1
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 22-34 doi: 10.1007/s11684-012-0178-6
Stroke is a personal, familial, and social disaster. It is the third cause of death worldwide, the first cause of acquired disability, the second cause of dementia, and its cost is astronomic. The burden of stroke is likely to increase given the aging of the population and the growing incidence of many vascular risk factors. Prevention of stroke includes—as for all other diseases—a “mass approach” aiming at decreasing the risk at the society level and an individual approach, aiming at reducing the risk in a given subject. The mass approach is primarily based on the identification and treatment of vascular risk factors and, if possible, in the implementation of protective factors. These measures are the basis of primary prevention but most of them have now been shown to be also effective in secondary prevention. The individual approach combines a vascular risk factor modification and various treatments addressing the specific subtypes of stroke, such as antiplatelet drugs for the prevention of cerebral infarction in large and small artery diseases of the brain, carotid endarterectomy or stenting for tight carotid artery stenosis, and oral anticoagulants for the prevention of cardiac emboli. There is a growing awareness of the huge evidence-to-practice gap that exists in stroke prevention largely due to socio-economic factors. Recent approaches include low cost intervention packages to reduce blood pressure and cheap “polypills” combining in a single tablet aspirin and several drugs to lower blood pressure and cholesterol. Polypill intake should however not lead to abandon the healthy life-style measures which remain the mainstay of stroke prevention.
关键词: stroke prevention vascular risk factors cerebral infarction cerebral hemorrhage anti-thrombotic drugs carotid endarterectomy
Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang
《医学前沿(英文)》 2021年 第15卷 第3期 页码 472-485 doi: 10.1007/s11684-021-0832-y
关键词: neuronal progenitor cells resveratrol cerebral ischemia neuronal differentiation mitochondrial metabolism positron emission tomography
White blood cell count and the incidence of hyperuricemia: insights from a community-based study
Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen
《医学前沿(英文)》 2019年 第13卷 第6期 页码 741-746 doi: 10.1007/s11684-017-0579-7
关键词: white blood cell count hyperuricemia chronic kidney disease inflammation
Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO
《化学科学与工程前沿(英文)》 2011年 第5卷 第3期 页码 392-400 doi: 10.1007/s11705-011-1202-0
关键词: electrospinning artificial blood vessels scaffold polyurethane gelatin nanofiber hemocompatibility
Study of blood exposure-related mental health illness among clinical nurses
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 147-151 doi: 10.1007/s11684-016-0481-8
Nurses are subjected to high amount of stress in the medical setting, and work-related stress often leads to mental problems. This study aims to investigate the mental health status of nurses exposed to blood through needlestick injuries. A total of 302 nurses working in the hospital of Guangdong, China, participated in this study. Out of the 302 nurses, 140 did not experience any needlestick injuries during the previous week, whereas 162 nurses experienced needlestick injuries. The General Health Questionnaire (GHQ)-28 Standardized Questionnaire, which uses physical, anxiety, social function, and depression subscales, was used in this study. No significant difference between nurses exposed to blood and nurses not exposed to blood was found in terms of gender, age, length of employment, and civil status (P>0.05). Results from the GHQ-28 Standardized Questionnaire showed that 75.9% (123/162) of nurses exposed to blood were suspected to suffer from mental disorders, whereas 40% (56/140) of nurses not exposed to blood were suspected to suffer from mental disorders. The mean mental health scores of nurses exposed to blood and those not exposed were 8.73±7.32 and 5.69±5.70, respectively. From these results, we can conclude that blood exposure from needlestick injuries leads to higher prevalence of depression, anxiety, and stress symptoms in nurses. This finding highlights the importance of providing efficient, adequate, and appropriate support services after nurses are exposed to blood from needlestick injuries.
关键词: blood exposure needlestick injuries mental health nurses
Endostatin specifically targets both tumor blood vessels and lymphatic vessels
Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo
《医学前沿(英文)》 2011年 第5卷 第4期 页码 336-340 doi: 10.1007/s11684-011-0163-5
关键词: endostatin angiogenesis lymphangiogenesis nystatin internalization tumor
Intracellular trehalose improves the survival of human red blood cells by freeze-drying
HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng
《能源前沿(英文)》 2007年 第1卷 第1期 页码 120-124 doi: 10.1007/s11708-007-0014-x
陈灏珠,金雪娟
《中国工程科学》 2002年 第4卷 第11期 页码 1-6
回顾分析50年来我国健康人群血脂水平的变化,结果显示血总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)随年龄而增高,50岁以前男女间无差别,50岁以后女性高于男性,城市居民高于农村居民;高密度脂蛋白胆固醇(HDL-C)随年龄的变化不明显,男性低于女性;血TC、TG和LDL-C随年代而增高,20世纪90年代末达最高峰,而HDL-C则下降;血TC高于正常者(>200~220 mg/dL)男性占17.8 %~54.9 %,女性占14.9 %~53.4 %,也随年代而增多;血脂水平的变化与饮食结构转变为低碳水化合物、高脂肪、高胆固醇有关。对策:恢复健康的饮食习惯,摄取平衡饮食;建立良好生活习惯,减少其他心血管病危险因素,特别建议进行体育锻炼;已有血脂异常,经饮食调节和体育锻炼3个月以上仍未见好转者,宜接受调脂药物治疗。
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
《医学前沿(英文)》 2008年 第2卷 第1期 页码 19-24 doi: 10.1007/s11684-008-0005-2
关键词: therapy Sprague administration cardiac hypertrophy valsartan
Using hybrid models to predict blood pressure reactivity to unsupported back based on anthropometric
Gurmanik KAUR,Ajat Shatru ARORA,Vijender Kumar JAIN
《信息与电子工程前沿(英文)》 2015年 第16卷 第6期 页码 474-485 doi: 10.1631/FITEE.1400295
关键词: Blood pressure (BP) Principal component analysis (PCA) Forward stepwise regression Artificial neural network (ANN) Adaptive neuro-fuzzy inference system (ANFIS) Least squares support vector machine (LS-SVM)
标题 作者 时间 类型 操作
Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profileand blood glucose level
TANG Zhongzhi, LI Junyao, YANG Jianhong
期刊论文
Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral
null
期刊论文
survival and neuronal differentiation of hypoxia-conditioned neuronal progenitor cells in rats with cerebral
Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang
期刊论文
White blood cell count and the incidence of hyperuricemia: insights from a community-based study
Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen
期刊论文
gelatin-heparin nanofibrous scaffolds formed by a bi-layer electrospinning technique as potential artificial blood
Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO
期刊论文
Endostatin specifically targets both tumor blood vessels and lymphatic vessels
Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo
期刊论文
Intracellular trehalose improves the survival of human red blood cells by freeze-drying
HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng
期刊论文
Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
期刊论文